Providing innovation in personalized medicine for breast cancer chemotherapy management.

Rna Diagnostics is a cancer diagnostics company providing  a platform of prognostic biomarker tools to help improve the lives of women undergoing chemotherapy for breast cancer. Founded in 2010, Rna Diagnostics’ first product is the RNA Disruption Assay™.

The RNA Disruption Assay™ (RDA™) provides physicians with an evaluation of how individual patients are responding to chemotherapy. If chemotherapy is working, the physician and patient can continue treatment with confidence. If chemotherapy is not working well enough, physicians may consider alternate therapies. For patients, this means avoiding harmful side effects and the possibility for improved survival outcomes.

Rna Diagnostics has clinical trials and collaborations in progress at multiple clinical research centres in Canada, Germany, Italy, Japan, Sweden, United Kingdom and the United States. The RNA Disruption Assay is available for clinical trial use from a state-of-the-art laboratory in Sudbury, Ontario, Canada.

Rna Diagnostics has the worldwide exclusive license from Laurentian University for this technology. It is anticipated that this technology will substantially improve the current treatment landscape for breast and other types of cancers.

Working with physicians across the globe,
Rna Diagnostics aims to
improve chemotherapy management,
improve the quality of life for cancer patients
and reduce healthcare costs.

Read what Professor Daniele Generali, RDA Clinical Research Collaborator has to say about Rna Diagnostics

Professor Daniele Generali

“RDA represents a major advance in the management of breast cancer therapy. It offers the promise of real time monitoring of patient response to chemo treatment. RDA will allow us to make better informed treatment decisions that will improve the lives of our patients.”

Associate Professor in Medical Oncology
Department of Medical, Surgery and Health Sciences, University of Trieste, Piazza Ospitale 1, Trieste, Italy

Meet the Rna Diagnostics Team

An experienced management team and a world renowned clinical advisory board providing a Real Time chemotherapy guidance tool

Rna Team

Jeremy Bridge-Cook Ph.D.
Jeremy Bridge-Cook Ph.D.President and Chief Executive Officer

Dr. Jeremy Bridge-Cook worked at Luminex Corporation and Tm Bioscience (TMB, acquired by Luminex in 2007) for 16 years in positions of increasing responsibility. Dr. Bridge-Cook was VP of Business Development, VP Sales & Marketing and Senior VP Corporate Development at TMB, and most recently served as Senior VP of Research & Development at Luminex Corp. Prior to working at Luminex/TMB, Dr. Bridge-Cook worked as an Investment Manager at MDS Capital Corp., a venture capital company focused on Life Science investments. Dr. Bridge-Cook received his B.Sc. from McMaster University and Ph.D. of Immunology from the University of Toronto.

Ken Pritzker - MD, FRCPC
Ken Pritzker - MD, FRCPCChief Innovation Officer

Former Chief of Pathology, Mount Sinai Hospital and currently Professor emeritus, Laboratory Medicine and Pathobiology University of Toronto, Dr. Ken Pritzker is recognized internationally for leadership in laboratory medicine, biomedical research and practical experience bringing new diagnostic tests into practice. Dr. Pritzker has extensive experience introducing innovative companion diagnostics for cancer therapy.

Amadeo Parissenti - Ph.D.
Amadeo Parissenti - Ph.D.Chief Scientific Officer

Professor of Chemistry and Biochemistry at Laurentian University and Cancer Research Chair, Regional Cancer Program, Sudbury Hospital, Dr. Amadeo Parissenti is an authority on drug resistance in breast cancer and conducts translational research studies in association with the National Cancer Institute of Canada and other major clinical trial Groups.

John Connolly
John ConnollyVP Corporate Development

John Connolly, in his role as VP Corporate Development, works with commercial partners and clinical collaborators to foster clinical adoption of RDA into oncology practice, clinical trials and cancer research worldwide. John was a venture partner at MDS Capital Corp., a Toronto based health sciences venture investor where he led investments in Medtech startups, including Catamaran Corp. acquired by United Health Group for $12.8 Billion in 2015.
“RDA is a game changing technology. It enables a rational approach to chemotherapy where treatment decisions are informed by the individual patient’s response to a treatment in real time. I believe that this ‘Response Guided Therapy’ will enable doctors to provide their patients with truly personalized cancer treatment.”

John Jordan - MBA, CPA, CMA
John Jordan - MBA, CPA, CMAChief Financial Officer

A financial executive and entrepreneur, John Jordan has over 20 years working with entrepreneurs to create and build companies in the financial and medical technology sectors.

Laura Pritzker - PhD
Laura Pritzker - PhDPrincipal Scientist

With over 15 years of research experience in academic and industrial environments, as well as laboratory research experience in protein chemistry and cell and molecular biology, Dr. Laura Pritzker brings specific industrial experience in RNA diagnostic assay. She is responsible for development and optimization of RNA Disruption Assay, as well as project management and development. Dr. Pritzker earned her PhD in Pathobiology and Laboratory Medicine from the University of Toronto.

“I’m excited about taking this fundamental biological drug effect on RNA structure and using it to improve the care of women who are undergoing treatment for breast cancer.”

Sanaa Noubir - Ph.D., MBA
Sanaa Noubir - Ph.D., MBAClinical Development Manager

With a PhD in Genetics and Molecular Biology from the University of Paris Sud XI, Orsay, France, Dr. Sanaa Noubir brings a wealth of experience and knowledge in cell biology to Rna Diagnostics. Dr. Noubir’s focus is on the development and management of collaborations with clinical partners. Dr. Noubir also has an MBA from the Schulich School of Business, York University.

Board of Directors

John Connolly
John ConnollyVP Corporate Development

John Connolly, in his role as VP Corporate Development, works with commercial partners and clinical collaborators to foster clinical adoption of RDA into oncology practice, clinical trials and cancer research worldwide. John was a venture partner at MDS Capital Corp., a Toronto based health sciences venture investor where he led investments in Medtech startups, including Catamaran Corp. acquired by United Health Group for $12.8 Billion in 2015.
“RDA is a game changing technology. It enables a rational approach to chemotherapy where treatment decisions are informed by the individual patient’s response to a treatment in real time. I believe that this ‘Response Guided Therapy’ will enable doctors to provide their patients with truly personalized cancer treatment.”

Denis Ho
Denis HoFormer Managing Director, Life Sciences, BDC Venture Capital

Denis is a seasoned financial executive with a solid record of providing guidance and governance support to early stage Canadian healthcare and medtech companies.From 2002 to 2011, Denis was Managing Director of Life Sciences, BDC Venture, one of Canada’s most active life sciences and healthcare venture capital company. Prior to that, he was Vice President at MDS Capital, one of Canada’s leading venture investors in the field of biotechnology, medtech and healthcare. He has sat on over 20 boards of directors of early stage Canadian Life Sciences Companies.In addition to his 20 year career in venture capital, Denis spent several years in the financial services sector which included stints as Partner of Forbes Capital, Partner at KPMG and a commercial banker at the Mercantile Bank of Canada.Denis is an MSc graduate in medical microbiology from Queens University and has an MBA from the Ivey School of Business. He is also a graduate of the Not-for-Profit Governance Essentials Programme at the Institute of Corporate Governance, Rotman School of Business.

John Jordan - MBA, CPA, CMA
John Jordan - MBA, CPA, CMAChief Financial Officer

A financial executive and entrepreneur, John Jordan has over 20 years working with entrepreneurs to create and build companies in the financial and medical technology sectors.

Paul Lucas
Paul LucasFormer CEO, GSK Canada

Mr. Lucas served as President and CEO of GlaxoSmithKline Canada from 1994 until he retired in 2012. Previous to joining Glaxo Canada in 1986, he held progressive management positions at Eli Lilly Canada and McNeil Pharmaceutical.
Mr. Lucas also served as Chairman of the Board of Directors for TM Bioscience, a member of the Boards of Biochem Pharma, the Toronto Regional Research Alliance, Montreal inVivo, and AllerGen. In addition he was a member of the Principal’s Advisory Council of the University of Toronto at Mississauga, and a member of the Board of Trustees of Queen’s University. He also served as Chairman of the Board of Directors of Canada’s Research-Based Pharmaceutical Companies (Rx&D) for three terms.
Currently Mr. Lucas is a member of the Board of Directors of the Ontario Genomics Institute and ABcann Medicinals Inc., Chair of the Board of Induran Ventures Inc., advisor to Lumira Capital and RnA Diagnostics, an Associate of SHI Consulting, and Chair of the Board of Life Sciences Ontario.
He received his BSc (Honours) in Biology and Chemistry from Queen’s University, and obtained his Chartered Directors designation (CDir) from the Directors College, a joint venture of McMaster University and the Conference Board of Canada, in 2009.

Ken Pritzker - MD, FRCPC
Ken Pritzker - MD, FRCPCChief Innovation Officer

Former Chief of Pathology, Mount Sinai Hospital and currently Professor emeritus, Laboratory Medicine and Pathobiology University of Toronto, Dr. Ken Pritzker is recognized internationally for leadership in laboratory medicine, biomedical research and practical experience bringing new diagnostic tests into practice. Dr. Pritzker has extensive experience introducing innovative companion diagnostics for cancer therapy.

Clinical Advisory Board

Maureen E. Trudeau, MA, MD, FRCPC
Maureen E. Trudeau, MA, MD, FRCPC

Dr. Maureen Trudeau is one of Canada’s leading breast cancer research clinical scientists and practicing breast cancer specialists. Dr. Trudeau is a medical oncologist at Sunnybrook Health Sciences Centre, Odette Cancer Centre, and a professor in the, Department of Medicine, Faculty of Medicine, University of Toronto. As co-chair of breast cancer site group, Cancer Care Ontario. Dr. Trudeau has authored many guidelines on the treatment of breast cancer, which have influenced drug-funding decisions provincially and nationally. She was the principal investigator on the pivotal MA.22 clinical trial that led to the discovery of RDA and is committed to working with the company to turn RDA into a widely used clinical tool.
Having graduated with her MD from the University of Toronto and FRCPC from the Royal College of Physicians and Surgeons, Canada, Dr. Trudeau has had her research findings – covering many aspects of breast cancer from prevention to treatment – published in journals that include The New England Journal of Medicine and the Journal of Clinical Oncology. Dr. Trudeau also participates in clinical trials through the National Cancer Institute of Canada-Clinical Trials Group, the National Surgical Adjuvant Breast and Bowel Project, as well as in studies supported by grants from industry.

Gunter von Minckwitz, MD, Ph.D.
Gunter von Minckwitz, MD, Ph.D.

Gunter von Minckwitz is the President of the German Breast Group (GBG) Research Institute. GBG is the largest cooperative group in Germany working in the field of breast cancer with approximately 530 centres, 1100 collaborators and a recruitment of >40.000 breast cancer patients into prospective clinical trials. He is also Deputy Director at Senologic Oncology, Breast Centre in Düsseldorf and member of the Faculty of the University of Frankfurt, Germany.
Professor von Minckwitz received his medical education at the University of Heidelberg and completed his fellowship and residency at the Women’s Hospital, University of Heidelberg, and the Women’s Hospital, University of Frankfurt, Germany. His areas of research include systemic treatment in all stages of the disease (neo-adjuvant, adjuvant, metastatic treatment and chemoprevention), where he has participated and led a large number of national and international clinical trials. He led the development of the national treatment guideline for breast cancer of the AGO from 2001 until 2006.
Professor von Minckwitz has authored and co-authored >270 medline listed scientific papers including, NEJM, Lancet, JCO, JNCI, in addition to 800 review articles, book chapters and printed abstracts, as well as 20 books. He was on the board of directors of the Breast International Group (BIG) from 2003-2014 and has become member of the St. Gallen consensus panel in 2008 and the Early Breast Cancer trialists’ collaborative group (EBCTCG) in 2010. He received the Wertheim Award in 2009 and the Claudia-Schilling Award in 2012 as well as the John-Mendelsohn Award of the German Cancer Society in 2012.

Michael Untch, MD, Ph.D.
Michael Untch, MD, Ph.D.

Michael Untch is Head of Clinic for Gynecology, Gynecologic Oncology and Obstetrics, as well as Head of Breast Interdisciplinary Cancer Center in the Department of Obstetrics and Gynecology of the HELIOS Klinkium in Berlin-Buch. After graduating from the Medical School at Ludwig Maximilians University in Munich, Professor Untch did his M.D. Thesis (Magna cum Laude) on “immunocytochemical detection of tumor cells in bone marrow of breast cancer patients at primary therapy.” He went on to become a post-doctoral research fellow at the Department of Gynecologic Oncology at University of Miami, a Fellow, Department of Obstetrics and Gynecology at Ludwig Maximilians University, and a board-certified obstetrician/gynecologist.
Professor Untch is the author or co-author of more than 400 scientific publications. His current research projects include hormone and growth factor receptors in gynecologic oncology; new therapies in breast cancer; minimal-invasive diagnosis and therapeutic techniques in gynecologic oncology; mutation spectrum in familial breast and ovarian cancer; and prognostic and predictive factors in breast cancer.
Professor Untch sits on six editorial boards, including Der Onkolonge, Springer and Breast Care, Karger, and has more than a dozen professional memberships. The latter includes the German Cancer Society, American Society of Clinical Research, German Society of Gynecology and Obstetrics and Breast International Group.

Harry D. Bear, MD, Ph.D.
Harry D. Bear, MD, Ph.D.

Dr. Bear is the Walter Lawrence, Jr. Distinguished Professor in Oncology, Chairman of the Division of Surgical Oncology, Professor of Surgery and Microbiology and Immunology. Dr. Bear graduated from Yale University cum laude, earned both his M.D. and Ph.D. at Virginia Commonwealth University, completed his surgical residency at Brigham and Women’s Hospital in Boston, and returned to VCU as a fellow in surgical oncology.
Dr. Bear’s clinical interests include breast cancer and other breast diseases, melanoma, sarcoma, and gastrointestinal cancers. His research interests include basic tumor immunology and T cell biology, pre-clinical and clinical studies of immunotherapy, translational clinical research trials, and breast cancer treatment trials. Dr. Bear has authored more than 150 articles and book chapters. His work has been published in several prestigious journals, including New England Journal of Medicine, Journal of Clinical Oncology, Journal of Surgical Oncology, and Annals of Surgical Oncology. He has been on the Board of Directors of the National Surgical Adjuvant Breast and Bowel Project (NSABP) for more than twenty years and has been Study Chair for two of this group’s international breast cancer trials. He is first author of two recent publications reporting on one of these trials, NSABP B-40, the first published in the New England Journal of Medicine in 2012 and the second was just published in Lancet Oncology in August, 2015.
Dr. Bear also serves the Massey Cancer Center in a variety of roles: leader of the Breast Cancer Clinical Research Team; Medical Director of the Clinical Research Office; and Chair of the Protocol Review and Monitoring Committee. He is the local principal investigator for most of Massey’s current breast cancer clinical trials, including a recently completed investigator-initiated trial that was supported by Genomic Health. Dr. Bear has also received many special honors, including the Sharon H. Kohlenberg Health Care Service Award from the Virginia Breast Cancer Foundation in 1995, the Distinguished Investigator Lifetime Achievement Award from the NSABP Foundation, Inc. In 2015, he was named to the National Surgical Adjuvant Breast and Bowel Project (NSABP) Foundation’s new board of directors.

Rna Diagnostics’ Supporters

Supporters include:

Georgian Angel Network
Golden Triangle Angelnet
Health Technology Exchange

Niagara Venture Forum
Northern Cancer Foundation
Ontario Centres of Excellence

Ontario Genomics Institute
Temple Rock Holdings
York Angel Investors

Rna Diagnostics receives support from organizations and individuals that believe RDA will provide critical information to physicians, improve the lives of women undergoing chemotherapy for breast cancer and will reduce healthcare costs.

Read what Nick Dipietro, Executive Director, Niagara Angel Network & Former President Of Patheon Inc. has to say about RDA

Nick Dipietro

“Rna Diagnostics’ RDA™ test will dramatically improve patient care and reduce health care costs. The underlying proprietary technology has the potential to create innovative products for the Canadian healthcare system and beyond. The experienced leadership team at Rna Diagnostics has the ability and drive to make this company a world success.”

Read what Dr. Maureen E. Trudeau has to say about RDA

Dr. Maureen E. Trudeau

“The RDA score could help us to predict which patients’ tumours will or will not respond to chemotherapy early in the course of treatment. This will allow a rapid change in treatment for those with unresponsive tumours.”

Co-author and Chair of the Rna Diagnostics Clinical Advisory Board, Dr. Maureen E. Trudeau Professor of Medicine at the University of Toronto, Medical Oncologist at the Odette Cancer Centre, Sunnybrook Health Sciences Centre, and co-chair of the breast cancer disease site group of Cancer Care Ontario.


For more information about investing in Rna Diagnostics, please contact:
John Connolly – Vice-President Corporate Development
416-985-4361 • jconnolly@rnadiagnostics.com

An evolution in breast cancer chemotherapy management.